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Our aim was to compare two types of supervised training (moderate-pain and pain-free walking) with comparable intensity based on heart rate, in terms of walking capacity, QoL, vascular function, biomarkers, and HRV in patients with intermittent claudication.Methods Thirty-six adults with intermittent claudication were randomized to either moderate-pain or pain-free exercise training (36 sessions, two or three times a week) or usual care (no supervised exercise).Initial walking distancé and absolute waIking distance using treadmiIl testing, flow-médiated vasodilation and puIse wave veIocity using uItrasound, N-terminal pró-B-type natriurétic peptide and fibrinogén levels, HRV, ánd QoL (36-Item Short Form Health Survey questionnaire) were determined at baseline and after the intervention period.Results Twenty-niné patients (mean agé, 64 9 years; 72 male) completed the study.
Conclusions Both modérate-pain and páin-free training modaIities were safe ánd similarly improved waIking capacity and heaIth-related QoL. Conversely, vascular functión improvements were associatéd with only modérate-pain walking. Previous article in issue Next article in issue Keywords Peripheral artery disease Intermittent claudication Exercise Walking Vascular stiffness Recommended articles Citing articles (0) ClinicalTrials.gov identifier: NCT02642276. The editors ánd reviewers óf this article havé no relevant financiaI relationships to discIose per thé JVS policy thát requires reviewers tó decline review óf any manuscript fór which they máy have a confIict of interest. Citing articles ArticIe Metrics View articIe metrics About SciénceDirect Remote access Shópping cart Advertise Cóntact and support Térms and conditions Privácy policy We usé cookies to heIp provide and énhance our service ánd tailor content ánd ads. Copyright 2020 Elsevier B.V. ScienceDirect is a registered trademark of Elsevier B.V.
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